When we talk about the most stubborn "last 10 pounds" we usually mean the weight loss plateau we hit when dieting. Sometimes the best diet is just a diet that's different from the one on which we were losing weight before the stalling. For example, a week out of a low carb and into a low fat vegetarian diet can do the trick.
However, there can be reasons that don't depend on diet's specifics and apply to any diet. They usually are:
Nutrient deficiency
Using wrong supplements
Subconscious cheating
Wrong exercise routines
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